Serum sclerostin level and its relation to subclinical atherosclerosis in the polycystic ovary syndrome phenotypes: A prospective controlled study
Open Access
- 27 September 2021
- journal article
- research article
- Published by Galenos Yayinevi in Journal of Turkish Society of Obstetric and Gynecology
- Vol. 18 (3), 167-174
- https://doi.org/10.4274/tjod.galenos.2021.51436
Abstract
Objective: We aim to study the relationship between atherosclerosis and serum sclerost in levels in different phenotypes of polycystic ovary syndrome (PCOS). Materials and Methods: A total of 134 women with PCOS and 33 age-matched controls participated in this study. Women with PCOS were further divided into subgroups based on their PCOS phenotypes: phenotype A (n=35), phenotype B (n=33), phenotype C (n=31), and phenotype D (n=35). Metabolic parameters, hormonal parameters, carotid intima-media thickness (CIMT), and sclerostin levels were compared among the PCOS phenotypes. Results: Statistically significant differences occurred among groups regarding follicle-stimulating hormone, luteinizing hormone, estradiol, total cholesterol, low-density lipoprotein, Ferriman-Gallwey score, total testosterone, and free androgen index. The mean CIMT was statistically higher in all PCOS phenotypes than in controls. In subgroup comparison, phenotypes A and B had a higher body mass index (BMI) adjusted CIMT than other phenotypes, respectively (p=0.005). Serum sclerostin levels were higher in PCOS patients than in controls. A concentration of >= 6.297 ng/mL showed a sensitivity of 56% and a specificity of 69.7% to predict PCOS. The BMI-adjusted sclerostin level was significantly higher in phenotype C (20.3 +/- 0.7 ng/mL) than in other phenotypes. Conclusion: Patients with phenotypes A and B seem to have an increased risk for atherosclerosis. Although sclerostin was higher in PCOS patients, we could not demonstrate the relation between sclerostin and atherosclerosis in different PCOS phenotypes.Keywords
This publication has 27 references indexed in Scilit:
- Insulin resistance and cardiovascular risk factors in women with PCOS who have normal glucose tolerance testGynecological Endocrinology, 2012
- The Wnt pathways in vascular diseaseCurrent Opinion in Lipidology, 2011
- Cardiovascular disease risk characteristics of the main polycystic ovary syndrome phenotypesEndocrine, 2011
- Carotid artery atherosclerosis in hypertensive patients with a functional LDL receptor-related protein 6 gene variantNutrition, Metabolism and Cardiovascular Diseases, 2011
- Diagnostic accuracy of flow-mediated dilatation and intima-media thickness for the presence of significant coronary artery diseaseJournal of the American Society of Hypertension, 2009
- Indicators for metabolic disturbances in anovulatory women with polycystic ovary syndrome diagnosed according to the Rotterdam consensus criteriaHuman Reproduction, 2008
- LRP6 Mutation in a Family with Early Coronary Disease and Metabolic Risk FactorsScience, 2007
- SOST/sclerostin, an osteocyte-derived negative regulator of bone formationCytokine & Growth Factor Reviews, 2005
- Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndromeFertility and Sterility, 2004
- Ultrasound assessment of the polycystic ovary: international consensus definitionsHuman Reproduction Update, 2003