Effect of Vitamin C, Hydrocortisone, and Thiamine vs Hydrocortisone Alone on Time Alive and Free of Vasopressor Support Among Patients With Septic Shock

Abstract

Sepsis is a life-threatening illness characterized by a dysregulated host response to infection.¹ It causes or contributes to between one-third and half of all hospital deaths² and is responsible for more than 5 million deaths worldwide each year.³ Patients with septic shock are an important sepsis subgroup and have circulatory and metabolic abnormalities that substantially increase their mortality risk.⁴ For these patients in particular, new treatments that improve outcomes are a global public health priority.