A mild and efficient method for the deprotection of trimethyl silyl alkynes using sodium ascorbate and copper sulphate
Open Access
- 31 December 2018
- journal article
- Published by European Journal of Chemistry in European Journal of Chemistry
Abstract
A competent and fast method for the deprotection of trimethyl silyl group was attained by using cheap, easily accessible, and nontoxic sodium ascorbate in combination with copper sulphate. The method labored was simple and effective for the cleavage of trimethyl silyl group from the protected trimethyl silyl alkynes to their corresponding alkyne derivatives. Wide functional group tolerance, shorter time period, simple procedure and high yields are the striking features of this protocol.Keywords
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