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Synthesis, characterization and antibacterial activity of (E)-chalcone derivatives

Ahmed Mutanabbi Abdula
Published: 30 September 2013
European Journal of Chemistry , Volume 4, pp 207-210; doi:10.5155/eurjchem.4.3.207-210.780

Abstract: (E)-Chalcone derivatives were synthesized by the Claisen-Schmidt condensation of aromatic aldehydes with methyl ketones. 5-Arylfuran-2-carboxaldehydes (1a-b) were synthesized by Meerwein´s method and condensed with 2-acetylpyrole or 2-acetylfuran to produce the new chalcone derivatives (2a-d). The new chalcones were characterized using FT-IR and GC-MS. The synthesized compounds were also screened against some bacterial species to evaluate their activity as promising antibacterial agents.
Keywords: antibacterial activity / chalcone derivatives / aldehydes / New Chalcones / condensed / Methyl ketones / Claisen Schmidt

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