Synthesis, characterization and antibacterial activity of (E)-chalcone derivatives
Open Access
- 30 September 2013
- journal article
- Published by European Journal of Chemistry in European Journal of Chemistry
- Vol. 4 (3), 207-210
- https://doi.org/10.5155/eurjchem.4.3.207-210.780
Abstract
(E)-Chalcone derivatives were synthesized by the Claisen-Schmidt condensation of aromatic aldehydes with methyl ketones. 5-Arylfuran-2-carboxaldehydes (1a-b) were synthesized by Meerwein´s method and condensed with 2-acetylpyrole or 2-acetylfuran to produce the new chalcone derivatives (2a-d). The new chalcones were characterized using FT-IR and GC-MS. The synthesized compounds were also screened against some bacterial species to evaluate their activity as promising antibacterial agents.Keywords
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