The irregularity-based topological indices are applied for computational evaluation of non-ordinary molecular graphs. The improvement of irregularity-primarily based total indices is associated at the conversion of a structural graph into a complete matter describing the irregularity of the molecular layout at the map. In structural science and chemistry, it is critical to be aware of how uncommon a molecular structure is in particular contexts and difficulties. In this paper, we discuss the QSPR analysis of sixteen irregularity indices and certain alkane structures.