Objective and Background: The process of sampling the air quality of chimney emissions is a job that has the risk of causing work-related disorders and diseases. This study examines the relationship between the risk of ergonomics in work postures with material safety data sheet complaints on sampling activities. Methods: Analytical observational method with cross sectional approach. using the Nordic Body Map questionnaire and the Rapid Entire Body Assessment (REBA) assessment sheet. Primary data and secondary data were analyzed using Rank Spearman statistical test. Results: The level of risk of ergonomics in work postures at each stage of activity varies from low risk (value 2-3), medium (value is 4-7), and high (value 8 -10). Meanwhile, the level of MSDscomplaints was low (score 28-49) 11.1%, moderate complaints (score 50-70) were 44.4% and high complaints (score 71-91) were 44.4%. The results of the analysis test showed that there was a relationship between the level of ergonomics risk of working postures at 6 stages of activity, namely pre sampling, side preparation, climbing stairs, raising equipment, lowering equipment, and descending stairs (p-value < 0.05). Conclusion: Based on the other 4 stages of activity, namely sampling with a probe, sampling with a gas analyzer, measuring water content, and measuring particulate levels, there is no relationship between the level of ergonomics in work posture and complaints of MSDs, to reduce the risk of M.S.D.s complaints, efforts can be made through redesigning work stations that are not ergonomic with the use of tools to reduce workload.