Poorly differentiated clusters and tumor budding are important prognostic factors in colorectal carcinomas
Open Access
- 3 September 2021
- journal article
- research article
- Published by Association of Basic Medical Sciences of FBIH in Bosnian Journal of Basic Medical Sciences
- Vol. 22 (2), 164-177
- https://doi.org/10.17305/bjbms.2021.6110
Abstract
The aim of our study was to assess the prognostic value of the two new grading systems based on the quantification of tumor budding - TB (GBd) and poorly differentiated clusters - PDCs (PDCs-G) in colorectal carcinomas (CRC). We performed a retrospective study on 71 CRC patients who underwent surgery at the Emergency County Hospital, Timișoara. CRC cases were classified based on haematoxylin-eosin slides, using the conventional grading system, GBd and PDCs-G, respectively. We used two-tier and three-tier grading schemes for each system. Subsequently, we evaluated associations with other prognostic factors in CRC. Based on the three-tier GBd (GBd-3t) most cases (34/69, 49.27%) were classified as G3Bd-3t, while based on the conventional grading system, the majority of the cases (55/69, 79.71%) were considered G2. On the other hand, based on the three-tier PDCs-G system (PDCs-G-3t), most cases (31/69, 44.93%) were PDCs-G2-3t. We also noted a more significant association of GBd-3t with other prognostic parameters analyzed, as compared to the conventional grading system. Nodal status, tumor stage, and lymphovascular invasion were strongly correlated with GBd-3t (p=0.0001). Furthermore, we noted that PDCs-G-3t correlated more significantly than the conventional grading system with nodal status (p<0.0001), tumor stage (p=0.0003), lymphovascular invasion (p<0.0001), perineural invasion (p=0.005) and the tumor border configuration (p<0.0001). High GBd and PDCs-G grades correlate directly with other negative prognostic factors in CRC.Thus, these new parameters/classification methods could be used as additional tools for risk stratification in patients with CRC.Keywords
This publication has 48 references indexed in Scilit:
- Colorectal Carcinoma Grading Quantified by Counting Poorly Differentiated ClustersThe American Journal of Surgical Pathology, 2013
- Colorectal carcinoma grading by quantifying poorly differentiated cell clusters is more reproducible and provides more robust prognostic information than conventional gradingVirchows Archiv A Pathological Anatomy and Histopathology, 2012
- Diagnostic reproducibility of tumour budding in colorectal cancer: a multicentre, multinational study using virtual microscopyHistopathology, 2012
- Tumour budding: a promising parameter in colorectal cancerBritish Journal of Cancer, 2012
- New Criteria for Histologic Grading of Colorectal CancerThe American Journal of Surgical Pathology, 2012
- Review of Histopathological and Molecular Prognostic Features in Colorectal CancerCancers, 2011
- Prognostic and predictive factors in colorectal cancerPostgraduate Medical Journal, 2008
- Histological Grading of Colorectal CancerAnnals of Surgery, 2008
- Interobserver agreement in grading of colorectal cancers—findings from a nationwide web‐based survey of histopathologistsHistopathology, 2008
- Prognostic value of tumor “budding” in patients with colorectal cancerDiseases of the Colon & Rectum, 1993