The aim of this work was to evaluate the lipid profile of Plasmodium berghei infected rats treated with aqueous extract of Cassia spectabilis. Twenty five (25) adult male wistar rats were divided into five (5) groups of five (5) rats per group. Group I was the normal control fed only rat chow and water, Group II was infected with the parasite without treatment. Groups III and IV were infected with Plasmodium berghei and afterwards treated with 200 mg/kg and 400 mg/kg of aqueous extract of Cassia spectabilis respectively, while Group V was infected and treated with a standard drug (chloroquine). Treatment lasted for 7 days after which animals were sacrificed and blood sample collected. Evaluation of lipid profile was performed by standard procedures. Plasmodium berghei infection significantly (PCassia spectabilis in a dose dependent manner. In conclusion, extract of the said plant wields the potential to recover a stable lipid profile in Plasmodium berghei infected rats.