Assessment of Left Ventricular Function using a Two-Dimensional Speckle Tracking Echocardiography in Asymptomatic Survivors of Hodgkin’s Lymphoma in Long-Term Follow-Up
- 1 November 2021
- journal article
- research article
- Published by Galenos Yayinevi in Istanbul Medical Journal
- Vol. 22 (4), 300-305
- https://doi.org/10.4274/imj.galenos.2021.07448
Abstract
Introduction: Two-dimensional speckle tracking echocardiography (2D-STE) is sensitive in the assessment of left ventricular (LV) systolic function and may aid in diagnosis of late cardiac effects in asymptomatic Hodgkin's lymphoma (HL) survivors in long-term follow-up. Methods: This is a cross-sectional study of 21 HL survivors previously treated with anthracyclines, with (8/21) or without-mediastinal (8/21) radiotherapy and no recurrence at least 3 years after treatment compared to age-matched 43 healthy volunteers. To assess long-term cardiac complications, we performed 12-lead electrocardiography and 2D transthoracic echocardiography. In addition to conventional echocardiographic parameters, we used tissue Doppler echocardiography for LV diastolic functions and 2D-STE for evaluating the global longitudinal strain (GLS) of the LV myocardium. Results: The mean age of the HL survivors was 40 +/- 15 years and the female sex was predominant (11/21). The average PR interval of the HL survivors was significantly longer (154.7 +/- 19.6 ms vs 133.8 +/- 13.9 ms, p<0.001) while the QTc interval was significantly shorter (383.8 +/- 18.7 ms vs 402.4 +/- 11.7 ms, p<0.001) than the control group. HL survivors had significantly impaired GLS compared to the control group (-193 +/- 2.6 vs-22.6 +/- 1.6, p<0.001). Thirteen of the HL survivors (61%) with normal LV ejection fraction had impaired GLS. The frequency of left ventricular diastolic dysfunction (LVDD) in the HL survivors group was significantly higher than that of the control group (52% vs 26%, p=0.015). Therefore, LVDD was detected in 61.5% of patients with a GLS <-20%. Conclusion: 2D-STE could be used in predicting late-onset subclinical cardiac side effects following treatment in asymptomatic HL survivors for long-term follow-up.This publication has 22 references indexed in Scilit:
- Independent and Incremental Value of Deformation Indices for Prediction of Trastuzumab-Induced CardiotoxicityJournal of the American Society of Echocardiography, 2013
- Normal Ranges of Left Ventricular Strain: A Meta-AnalysisJournal of the American Society of Echocardiography, 2013
- Assessment of Echocardiography and Biomarkers for the Extended Prediction of Cardiotoxicity in Patients Treated With Anthracyclines, Taxanes, and TrastuzumabCirculation: Cardiovascular Imaging, 2012
- Changes in Left Ventricular Longitudinal Strain with Anthracycline Chemotherapy in Adolescents Precede Subsequent Decreased Left Ventricular Ejection FractionJournal of the American Society of Echocardiography, 2012
- Cardiovascular Status of Childhood Cancer Survivors Exposed and Unexposed to Cardiotoxic TherapyJournal of Clinical Oncology, 2012
- Diastolic Dysfunction in Patients with Type 2 Diabetes Mellitus: Is It Really the First Marker of Diabetic Cardiomyopathy?Journal of the American Society of Echocardiography, 2011
- Clinically significant cardiac disease in patients with Hodgkin lymphoma treated with mediastinal irradiationBlood, 2011
- Early Epirubicin-Induced Myocardial Dysfunction Revealed by Serial Tissue Doppler Echocardiography: Correlation with Inflammatory and Oxidative Stress MarkersThe Oncologist, 2007
- Late cardiotoxicity after treatment for Hodgkin lymphomaBlood, 2006
- Diastolic dysfunction after mediastinal irradiationAmerican Heart Journal, 2005