Climate change and soil health are intertwined complex processes that affect each other. The aim of this review was to find out the impact of climate change on soil health, its implication on food security and human welfare across the globe. The study found out that soil health is affected by land use practices and several anthropogenic activities carried out on landscapes; climate change and variability. Soil health also contributes to soil water retention, crop productivity, households’ food and income security culminating into a large contribution towards achieving sustainable development goals across the globe. Soil components affect climate and climate affects soil health and human wellbeing. The review article concluded that climate change and soil health are complex and intertwined multidisciplinary processes that require multidisciplinary approaches for better understanding and improvement of crop production. Appropriate climate smart agricultural practices are recommended to enhance soil health and mitigate and adapt to the changing climate for the improved farmers’ income, food security and human wellbeing across the globe.