World Workshop on Oral Medicine VII: Prognostic biomarkers in oral leukoplakia and proliferative verrucous leukoplakia—A systematic review of retrospective studies
- 19 April 2020
- journal article
- review article
- Published by Wiley in Oral Diseases
- Vol. 27 (4), 848-880
- https://doi.org/10.1111/odi.13363
Abstract
Objective To systematically review retrospective studies examining prognostic potentials of candidate biomarkers to stratify malignant progression of oral leukoplakia (OL) and proliferative verrucous leukoplakia (PVL). Materials and Methods A systematic literature search of PubMed, EMBASE, Evidence‐Based Medicine and Web of Science databases targeted literature published through March 29, 2018. Interrater agreement was ascertained during title, abstract and full‐text reviews. Eligibility evaluation and data abstraction from eligible studies were guided by pre‐defined PICO questions and bias assessment by the Quality in Prognosis Studies tool. Reporting followed Preferred Reporting Items for Systematic Review and Meta‐Analysis criteria. Biomarkers were stratified based on cancer hallmarks. Results Eligible studies (n=54/3,415) evaluated 109 unique biomarkers in tissue specimens from 2,762 cases (2,713 OL, 49 PVL). No biomarker achieved benchmarks for clinical application to detect malignant transformation. Interrater reliability was high, but 65% of included studies had high ‘Study Confounding’ bias risk. Conclusion There was no evidence to support translation of candidate biomarkers predictive of malignant transformation of OL and PVL. Systematically‐designed, large, optimally‐controlled, collaborative, prospective, longitudinal studies with a priori‐specified methods to identify, recruit, prospectively follow, and test for malignant transformation are needed to enhance feasibility of prognostic biomarkers predicting malignant OL or PVL transformation.Funding Information
- University of Melbourne
- National Institute of Dental and Craniofacial Research
- Unilever
This publication has 77 references indexed in Scilit:
- The Combination of SMAD4 Expression and Histological Grade of Dysplasia Is a Better Predictor for the Malignant Transformation of Oral LeukoplakiaPLOS ONE, 2013
- Loss of Heterozygosity (LOH) Profiles—Validated Risk Predictors for Progression to Oral CancerCancer Prevention Research, 2012
- EZH2 Promotes Malignant Phenotypes and Is a Predictor of Oral Cancer Development in Patients with Oral LeukoplakiaCancer Prevention Research, 2011
- Two stem cell markers, ATP‐binding cassette, G2 subfamily (ABCG2) and BMI‐1, predict the transformation of oral leukoplakia to cancerCancer, 2011
- Oral premalignant lesions: from a clinical perspectiveInternational Journal of Clinical Oncology, 2011
- Immunohistochemical expression of p16INK4A protein as a helpful marker of a subset of potentially malignant oral epithelial lesions: study on a series with long‐term follow‐upHistopathology, 2010
- Clinicopathological features and immunohistochemical expression of p53, Ki-67, Mcm-2 and Mcm-5 in proliferative verrucous leukoplakiaJournal of Oral Pathology & Medicine, 2010
- Potentially malignant and malignant lesions of the lip. Role of silver staining nucleolar organizer regions, proliferating cell nuclear antigen, p53, and c‐myc in differentiation and prognosisJournal of Oral Pathology & Medicine, 1999
- Salivary gland duct involvement in oral epithelial dysplasia and squamous cell carcinomaOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 1996