New Horizons for Dissecting Epistasis in Crop Quantitative Trait Variation
- 23 November 2020
- journal article
- review article
- Published by Annual Reviews in Annual Review of Genetics
- Vol. 54 (1), 287-307
- https://doi.org/10.1146/annurev-genet-050720-122916
Abstract
Uncovering the genes, variants, and interactions underlying crop diversity is a frontier in plant genetics. Phenotypic variation often does not reflect the cumulative effect of individual gene mutations. This deviation is due to epistasis, in which interactions between alleles are often unpredictable and quantitative in effect. Recent advances in genomics and genome-editing technologies are elevating the study of epistasis in crops. Using the traits and developmental pathways that were major targets in domestication and breeding, we highlight how epistasis is central in guiding the behavior of the genetic variation that shapes quantitative trait variation. We outline new strategies that illuminate how quantitative epistasis from modified gene dosage defines background dependencies. Advancing our understanding of epistasis in crops can reveal new principles and approaches to engineering targeted improvements in agriculture.Keywords
This publication has 114 references indexed in Scilit:
- Interlocking Feedback Loops Govern the Dynamic Behavior of the Floral Transition inArabidopsisTHE PLANT CELL ONLINE, 2013
- Epistasis in tomato color mutations involves regulation of phytoene synthase 1 expression by cis -carotenoidsProceedings of the National Academy of Sciences of the United States of America, 2012
- Gene balance hypothesis: Connecting issues of dosage sensitivity across biological disciplinesProceedings of the National Academy of Sciences of the United States of America, 2012
- Increase in Tomato Locule Number Is Controlled by Two Single-Nucleotide Polymorphisms Located NearWUSCHELPlant Physiology, 2011
- Distribution ofSUN, OVATE, LC, andFASin the Tomato Germplasm and the Relationship to Fruit Shape DiversityPlant Physiology, 2011
- HeterosisTHE PLANT CELL ONLINE, 2010
- The Role of Recently Derived FT Paralogs in Sunflower DomesticationCurrent Biology, 2010
- The Soybean Stem Growth Habit Gene Dt1 Is an Ortholog of Arabidopsis TERMINAL FLOWER1Plant Physiology, 2010
- Rin4 Causes Hybrid Necrosis and Race-Specific Resistance in an Interspecific Lettuce HybridTHE PLANT CELL ONLINE, 2009
- Epistasis — the essential role of gene interactions in the structure and evolution of genetic systemsNature Reviews Genetics, 2008