Central nervous system diseases associated with blood brain barrier breakdown - A Comprehensive update of existing literatures
Open Access
- 25 August 2020
- journal article
- Published by Heighten Science Publications Corporation in Journal of Neuroscience and Neurological Disorders
- Vol. 4 (2), 053-062
- https://doi.org/10.29328/journal.jnnd.1001035
Abstract
Blood vessels that supply and feed the central nervous system (CNS) possess unique and exclusive properties, named as blood–brain barrier (BBB). It is responsible for tight regulation of the movement of ions, molecules, and cells between the blood and the brain thereby maintaining controlled chemical composition of the neuronal milieu required for appropriate functioning. It also protects the neural tissue from toxic plasma components, blood cells and pathogens from entering the brain. In this review the importance of BBB and its disruption causing brain pathology and progression to different neurological diseases like Alzheimer’s disease (AD), Parkinson’s disease (PD), Amyotrophic lateral sclerosis (ALS), Huntington’s disease (HD) etc. will be discussed.Keywords
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