Microwave Irradiation Effect on Intermolecular and Intramolecular Friedel-Crafts Acylation Reaction

Abstract

The effect of microwave irradiation on the intermolecular and intramolecular Friedel-Crafts acylation of aromatic compounds was investigated. Microwave irradiation had no effect on the intermolecular reaction but had an accelerating effect on the intramolecular reaction. This enhanced intramolecular reactivity that was attributed to the high probability of close proximity between the reaction sites.