Close Correlation between Frailty and Depressive State in Chronic Liver Diseases
Open Access
- 27 June 2020
- Vol. 56 (7), 319
- https://doi.org/10.3390/medicina56070319
Abstract
Background and objectives: Few data with regard to the relevance between depression and frailty in chronic liver disease (CLD) patients are currently available. We aimed to elucidate the relationship between frailty and depression as evaluated by the Beck Depression Inventory—2nd edition (BDI-II) in CLD patients (n = 340, median age = 65.0 years). Methods: Frailty was defined as a clinical syndrome in which three or more of the following criteria were met: body weight loss, exhaustion, muscle weakness, slow walking speed and low physical activity. Depressive state was defined as BDI-II score 11 or greater. Results: Robust (frailty score = zero), prefrail (frailty score = one or two) and frailty were identified in 114 (33.5%), 182 (53.5%) and 44 (12.9%). The median BDI-II score was five. Depressive state was identified in 84 patients (24.7%). The median BDI-II scores in patients with robust, prefrail and frail traits were 2, 7 and 12.5 (robust vs. prefrail, p < 0.0001; prefrail vs. robust, p = 0.0003; robust vs. frail, p < 0.0001; overall p < 0.0001). The proportions of depressive state in patients with robust, prefrail and frail traits were 3.51%, 30.77% and 54.55% (robust vs. prefrail, p < 0.0001; prefrail vs. robust, p = 0.0046; robust vs. frail, p < 0.0001; overall p < 0.0001). BDI-II score significantly correlated with frailty score (rs = 0.5855, p < 0.0001). Conclusions: The close correlation between frailty and depression can be found in CLD. Preventing frailty in CLD should be approached both physiologically and psychologically.Keywords
This publication has 37 references indexed in Scilit:
- Changes in frailty are associated with waitlist mortality in patients with cirrhosisJournal of Hepatology, 2020
- Physical Function, Physical Activity, and Quality of Life After Liver TransplantationLiver Transplantation, 2020
- Frailty—A promising concept to evaluate disease vulnerabilityMechanisms of Ageing and Development, 2020
- Clinical utility of the Liver Frailty Index for predicting muscle atrophy in chronic liver disease patients with hepatocellular carcinomaHepatology Research, 2019
- Frailty and the Burden of Concurrent and Incident Disability in Patients With Cirrhosis: A Prospective Cohort StudyHepatology Communications, 2019
- Frailty Associated With Waitlist Mortality Independent of Ascites and Hepatic Encephalopathy in a Multicenter StudyGastroenterology, 2019
- Predicting Hepatic Encephalopathy-Related Hospitalizations Using a Composite Assessment of Cognitive Impairment and Frailty in 355 Patients With CirrhosisThe American Journal of Gastroenterology, 2018
- Implications of frailty screening in clinical practiceCurrent Opinion in Clinical Nutrition and Metabolic Care, 2017
- Frailty as Tested by Gait Speed is an Independent Risk Factor for Cirrhosis Complications that Require HospitalizationThe American Journal of Gastroenterology, 2016
- Systematic review of the Kihon Checklist: Is it a reliable assessment of frailty?Geriatrics & Gerontology International, 2016