Background Political neuroimaging is an emerging field investigating neurological roots of political behavior, while many brain imaging techniques such as magnetic resonance imaging (MRI) and functional MRI provide quantifiable information. However, the literature is scarce on its practical applications in political sciences since it's unclear how it impacts political sciences. Put it simply, how the developments in neuroimaging can be used as a tool in politics, especially to monitor and assess their decision-making related to criminal acts such as corruption, is unclear. In addition, there are potential ethical limitations preventing investigators from using brain imaging to evaluate and monitor the behavior of politicians. AIMS: The aim of the study was to discuss the potential role of neuroimaging as a political tool. Neuroimaging tools can help us demonstrate specific abnormal behavior associated with politically unethical behavior, such as corruption or deceptive behavior. However, documenting brain imaging findings specific to such deviant behavior may be challenging. Here, we suggest that the practical use of political neuroimaging can improve transparency in the political field. It can be recommended to analyze and have insights into the decision-making process of politicians. Furthermore, neurofeedback tools such as electroencephalography can be used to improve politicians' decision-making. METHODS: We have searched relevant articles using Google Scholar search engine. However, this study is not a systematic review. Thus, in this manuscript, we have speculated on the potential of measuring politically inappropriate behavior such as corruption and deceptive conduct.