The article considers the research results of psychological features of regulation of activity and socio-psychological adaptation of managers with various levels of neuroticism. A hypothesis was put forward before starting work regarding the influence of neuroticism on the components of socio-psychological adaptation in people working in the field of management and their correlations. A common set of methods was chosen for the study: a method for diag-nosing socio-psychological adaptation (Diamond R. E., 2004), a method for diagnosing self-assessment of mental states (Eysenck H., 1963), a method for diagnosing the level of neuroticism (Wasserman L. I., 1987), a method for measuring rigidity (Eysenck H., 1965), a method for express diagnosis of neurosis (Hess H., Heck K., 1975). These methods made it possible to identify and quantify the level of neuroticism among respondents and the characteristics of their psycho-logical state, including the level of adaptation, self-acceptance, acceptance of other people, emotional comfort, internali-ty, the desire to dominate, anxiety, aggressiveness, frustration, rigidity, etc. It was found that the level of neuroticism really has an impact on the characteristics of socio-psychological adaptation and its components after analyzing and comparing the results. It was revealed that with an increase in the level of neuroticism, there is a deterioration in the psychological regulation of activity and socio-psychological adaptation of the individual. It can be seen from the re-search results that respondents with high neuroticism have an increased level of anxiety, frustration, aggression and rigidity, as well as tension and difficulty in adapting. Such people do not fully accept themselves and others, have a worse level of emotional comfort, they have an increased level of desire to dominate; they more often attribute responsibility for the results of their activities or the situation around them to other circumstances or a “decision” of fate. Respondents with a low level of neuroticism have the best indicators of psychological regulation of their activities and socio-psychological adaptation.