Infrared Spectral Digital Imaging and Bone Cancer Diagnostic
Open Access
- 28 March 2022
- journal article
- Published by IntechOpen in Digital Medicine and Healthcare Technology
- Vol. 2022, 1-18
- https://doi.org/10.5772/dmht.05
Abstract
Scientists today are pursuing the development of non-destructive and non-invasive methods for rapid and reliable diagnosis of diseases in digital form and reduction in the need for biopsies. In this paper we review the most recent studies supporting the application of Fourier Transform Infrared (FT-IR) spectroscopy and infrared thermography or medical thermography. Both are non-destructive digital techniques, which are promising to record and discriminate the local biochemical changes that are induced by the diseases, while the examined samples do not need any special preparation. The reflected infrared radiation from the affected areas of the body strongly depends on the metabolic steps of the cancer/or any other disease, which is also related to the structural changes at a molecular level of the biological molecules during enzymatic or non-enzymatic steps of the disease. The detection of the FT-IR spectral digital “marker bands” of the obtained changes of cell, liquids or tissue components are derived from the disease in the check point. Furthermore, ImageJ analysis of the thermal imaging in cancerous area showed aggregate formation upon cancer development as it was also indicated from the FT-IR spectra.Keywords
This publication has 76 references indexed in Scilit:
- Role of HGF in epithelial–stromal cell interactions during progression from benign breast disease to ductal carcinoma in situBreast Cancer Research, 2013
- Infrared Assessment of Bone Quality: A ReviewClinical Orthopaedics and Related Research, 2011
- New standards for devices used for the measurement of human body temperatureJournal of Medical Engineering & Technology, 2010
- Microimaging FT-IR spectroscopy on pathological breast tissuesVibrational Spectroscopy, 2009
- Spectroscopic markers of bone quality in alendronate-treated postmenopausal womenOsteoporosis International, 2008
- Infrared thermal imaging as a tool in university physics educationEuropean Journal of Physics, 2007
- Peer Reviewed: IR Spectroscopy in Clinical and Diagnostic ApplicationsAnalytical Chemistry, 2004
- Liquid crystal thermography in the diagnosis of scaphoid fractures.Emergency Medicine Journal, 1987
- The diagnosis of stress fractures in athletesJAMA, 1984
- Raman Spectroscopy: A structural probe of glycosaminoglycansBiochimica et Biophysica Acta (BBA) - General Subjects, 1978