Retracted: Kinesin family member 3A stimulates cell proliferation, migration, and invasion of bladder cancer cells in vitro and in vivo

Abstract

Bladder cancer is one of the most common malignant tumors of the urinary system, with high morbidity and mortality. At present, the survival rates and prognosis of patients with bladder cancer are still relatively low, and thus there remains a need to improve prognosis by identifying novel targets. Kinesins (Kinesin super family proteins) are a series of microtubule‐based motor proteins which mediate various types of cellular processes. Kinesin family member 3A (KIF3A) is critical for cytoplasm separation in mitosis, and has been reported to be misexpressed in multiple types of cancers. However, its effects on the progression and development of bladder cancer remain unclear. Herein, we report that KIF3A is highly expressed in human bladder cancer. We identified a significant correlation between KIF3A and clinical features, including clinical stage (*p=0.047), pathologic tumor status (*p=0.045), lymph node status (*p=0.041), and metastasis (*p=0.035). KIF3A expression was also correlated with poor prognosis of patients with bladder cancer. Our results further indicated that KIF3A ablation resulted in cell cycle arrest and blocked the proliferation, migration and invasion of bladder cancer cells in vitro, and restrained tumor growth in mice in a microtubule‐dependent manner. In summary, our findings suggest that KIF3A is a potential therapeutic target for bladder cancer.