Mathematical Model of COVID-19 Transmission Dynamics in South Korea: The Impacts of Travel Restrictions, Social Distancing, and Early Detection
Open Access
- 17 October 2020
- Vol. 8 (10), 1304
- https://doi.org/10.3390/pr8101304
Abstract
The novel coronavirus disease (COVID-19) poses a severe threat to public health officials all around the world. The early COVID-19 outbreak in South Korea displayed significant spatial heterogeneity. The number of confirmed cases increased rapidly in the Daegu and Gyeongbuk (epicenter), whereas the spread was much slower in the rest of Korea. A two-patch mathematical model with a mobility matrix is developed to capture this significant spatial heterogeneity of COVID-19 outbreaks from 18 February to 24 March 2020. The mobility matrix is taken from the movement data provided by the Korea Transport Institute (KOTI). Some of the essential patch-specific parameters are estimated through cumulative confirmed cases, including the transmission rates and the basic reproduction numbers (local and global). Our simulations show that travel restrictions between the epicenter and the rest of Korea effectively prevented massive outbreaks in the rest of Korea. Furthermore, we explore the effectiveness of several additional strategies for the mitigation and suppression of Covid-19 spread in Korea, such as implementing social distancing and early diagnostic interventions.Keywords
This publication has 27 references indexed in Scilit:
- Epidemiological and clinical features of the 2019 novel coronavirus outbreak in ChinaPublished by Cold Spring Harbor Laboratory ,2020
- Early dynamics of transmission and control of COVID-19: a mathematical modelling studyPublished by Cold Spring Harbor Laboratory ,2020
- Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: a modelling studyThe Lancet, 2020
- The role of mobility and health disparities on the transmission dynamics of TuberculosisTheoretical Biology and Medical Modelling, 2017
- The role of residence times in two-patch dengue transmission dynamics and optimal strategiesJournal of Theoretical Biology, 2015
- Evidence compendium and advice on social distancing and other related measures for response to an influenza pandemicPaediatric Respiratory Reviews, 2015
- The effect of public health interventions on the spread of influenza among citiesJournal of Theoretical Biology, 2012
- A methodology for performing global uncertainty and sensitivity analysis in systems biologyJournal of Theoretical Biology, 2008
- Reproduction numbers and sub-threshold endemic equilibria for compartmental models of disease transmissionMathematical Biosciences, 2002
- A structured epidemic model incorporating geographic mobility among regionsMathematical Biosciences, 1995