Clinicopathological and prognostic significance of long non-coding RNA-ROR in cancer patients
Open Access
- 9 July 2021
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Medicine
- Vol. 100 (27), e26535
- https://doi.org/10.1097/md.0000000000026535
Abstract
Background: Accumulating studies have focused on the clinicopathological and prognostic roles of large intergenic noncoding RNA regulator of reprogramming (lincRNA-ROR) in cancer patients. However, the results were controversial and unconvincing. Thus, we performed a meta-analysis to assess the associations between lincRNA-ROR expression and survival and clinicopathological characteristics of cancer patients. Methods: Hazard ratios for overall survival and disease-free survival with their 95% confidence intervals were used to evaluate the role of lincRNA-ROR expression in the prognosis of cancer patients. Risk ratios with their 95% confidence intervals were applied to assess the relationship between lincRNA-ROR expression and clinicopathological parameters. Results: A total of 18 articles with 1441 patients were enrolled. Our results indicated that high lincRNA-ROR expression was significant associated with tumor size, TNM stage, clinical stage, lymph metastasis, metastasis and vessel invasion of cancer patients. There were no correlations between high lincRNA-ROR expression and age, gender, infiltration depth, differentiation, serum CA19–9 and serum CEA of cancer patients. In addition, high lincRNA-ROR expression was associated with shorter Overall survival and disease-free survival on both univariate and multivariate analyses. Meanwhile, there were no obvious publication bias in our meta-analysis. Conclusions: LincRNA-ROR expression was associated with the clinicopathological features and outcome of cancer patients, which suggested that lincRNA-ROR might serve as a potential biomarker for cancer prognosis. Ethical approval: Since this study is on the basis of published articles, ethical approval and informed consent of patients are not required.Keywords
Funding Information
- Natural Science Foundation of Fujian Province (ZZ2019J13)
- the Youth Nursery Foundation of the Affiliated Southeast Hospital of Xiamen University, Zhangzhou, Fujian, China (17Y009)
This publication has 32 references indexed in Scilit:
- Altered expression of LINC-ROR in cancer cell lines and tissuesTumor Biology, 2015
- lincRNA-RoR and miR-145 Regulate Invasion in Triple-Negative Breast Cancer via Targeting ARF6Molecular Cancer Research, 2015
- LincRNA-ROR induces epithelial-to-mesenchymal transition and contributes to breast cancer tumorigenesis and metastasisCell Death & Disease, 2014
- Endogenous miRNA Sponge lincRNA-RoR Regulates Oct4, Nanog, and Sox2 in Human Embryonic Stem Cell Self-RenewalDevelopmental Cell, 2013
- Long noncoding RNA involvement in cancerBMB Reports, 2012
- Non-coding RNAs in human diseaseNature Reviews Genetics, 2011
- Long Intergenic Noncoding RNAs: New Links in Cancer ProgressionCancer Research, 2011
- lncRNAdb: a reference database for long noncoding RNAsNucleic Acids Research, 2010
- Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cellsNature Genetics, 2010
- The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaborationJournal of Clinical Epidemiology, 2009