Microbial Arsenal of Antiviral Defenses. Part II
Open Access
- 9 April 2021
- journal article
- review article
- Published by Pleiades Publishing Ltd in Biochemistry (Moscow)
- Vol. 86 (4), 449-470
- https://doi.org/10.1134/s0006297921040064
Abstract
Bacteriophages or phages are viruses that infect bacterial cells (for the scope of this review we will also consider viruses that infect Archaea). The constant threat of phage infection is a major force that shapes evolution of microbial genomes. To withstand infection, bacteria had evolved numerous strategies to avoid recognition by phages or to directly interfere with phage propagation inside the cell. Classical molecular biology and genetic engineering had been deeply intertwined with the study of phages and host defenses. Nowadays, owing to the rise of phage therapy, broad application of CRISPR-Cas technologies, and development of bioinformatics approaches that facilitate discovery of new systems, phage biology experiences a revival. This review describes variety of strategies employed by microbes to counter phage infection. In the first part defense associated with cell surface, roles of small molecules, and innate immunity systems relying on DNA modification were discussed. The second part focuses on adaptive immunity systems, abortive infection mechanisms, defenses associated with mobile genetic elements, and novel systems discovered in recent years through metagenomic mining.Keywords
This publication has 212 references indexed in Scilit:
- Mechanism of Foreign DNA Selection in a Bacterial Adaptive Immune SystemMolecular Cell, 2012
- Coordinated Regulation of Accessory Genetic Elements Produces Cyclic Di-Nucleotides for V. cholerae VirulenceCell, 2012
- CRISPR RNA maturation by trans-encoded small RNA and host factor RNase IIINature, 2011
- The phage‐host arms race: Shaping the evolution of microbesBioEssays, 2010
- Moonlighting bacteriophage proteins derepress staphylococcal pathogenicity islandsNature, 2010
- Antagonistic coevolution accelerates molecular evolutionNature, 2010
- RNA-Guided RNA Cleavage by a CRISPR RNA-Cas Protein ComplexCell, 2009
- Nucleation, propagation and cleavage of target RNAs in Ago silencing complexesNature, 2009
- Structural Basis for DNase Activity of a Conserved Protein Implicated in CRISPR-Mediated Genome DefenseStructure, 2009
- Origins and evolution of eukaryotic RNA interferenceTrends in Ecology & Evolution, 2008