In vivo human whole-brain Connectom diffusion MRI dataset at 760 µm isotropic resolution
Open Access
- 29 April 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Scientific Data
- Vol. 8 (1), 1-12
- https://doi.org/10.1038/s41597-021-00904-z
Abstract
We present a whole-brain in vivo diffusion MRI (dMRI) dataset acquired at 760 μm isotropic resolution and sampled at 1260 q-space points across 9 two-hour sessions on a single healthy participant. The creation of this benchmark dataset is possible through the synergistic use of advanced acquisition hardware and software including the high-gradient-strength Connectom scanner, a custom-built 64-channel phased-array coil, a personalized motion-robust head stabilizer, a recently developed SNR-efficient dMRI acquisition method, and parallel imaging reconstruction with advanced ghost reduction algorithm. With its unprecedented resolution, SNR and image quality, we envision that this dataset will have a broad range of investigational, educational, and clinical applications that will advance the understanding of human brain structures and connectivity. This comprehensive dataset can also be used as a test bed for new modeling, sub-sampling strategies, denoising and processing algorithms, potentially providing a common testing platform for further development of in vivo high resolution dMRI techniques. Whole brain anatomical T1-weighted and T2-weighted images at submillimeter scale along with field maps are also made available.Keywords
Funding Information
- U.S. Department of Health & Human Services | NIH | National Institute of Biomedical Imaging and Bioengineering (R01-EB019437, P41-EB030006, R01-EB020613, R01-EB019437, U01-EB025162, P41-EB015896, P41-EB030006)
- U.S. Department of Health & Human Services | NIH | National Institute of Biomedical Imaging and Bioengineering
- U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (K23-NS096056)
- U.S. Department of Health & Human Services | NIH | National Institute of Biomedical Imaging and Bioengineering
- U.S. Department of Health & Human Services | NIH | National Institute of Biomedical Imaging and Bioengineering
- U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R01-MH116173, U01-MH093765)
- U.S. Department of Health & Human Services | NIH | National Institute of Biomedical Imaging and Bioengineering
- U.S. Department of Health & Human Services | NIH | National Institute of Mental Health
- U.S. Department of Health & Human Services | NIH | National Institute of Biomedical Imaging and Bioengineering
- U.S. Department of Health & Human Services | NIH | National Institute of Biomedical Imaging and Bioengineering
- U.S. Department of Health & Human Services | NIH | National Center for Research Resources (S10-RR023401, S10-RR023043, S10-RR019307)
- U.S. Department of Health & Human Services | NIH | National Center for Research Resources
- U.S. Department of Health & Human Services | NIH | National Center for Research Resources
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