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Abnormal myocardial enzymes are important indicators of poor prognosis in COVID-19 patients

Jingping Cheng, Wanxin Liu, Siyang Chen, Xiafen Hu, Xiaochen Xiang, Zhongliang Cheng, Shaoqian Cai, Kaiwen Guo, , Xiaoliu Liu, Qingming Wu
Published: 1 April 2021
Future Virology , Volume 16, pp 265-276; doi:10.2217/fvl-2020-0304

Abstract: Objective: Researching the prognostic value of myocardial enzymes in COVID-19 patients. Materials & methods: We collected 113 confirmed COVID-19 patients. The dynamic changes of CK, LDH and α-HBDH in patients were studied retrospectively, the correlation between myocardial enzyme index, clinical classification and outcome of patients and its significance to prognosis. Results: There are significant statistical differences between LDH, α-HBDH, CK and the clinical classification, and patient’s outcome. In the receiver operating characteristic curve analysis, LDH, α-HBDH and CK have a good diagnostic value for the death outcome of patients. Conclusion: LDH, α-HBDH and CK were the components of myocardial enzyme profiles, and our results found that they were significantly positively correlated with clinical classification and prognosis of COVID-19 patients. The values of LDH, α-HBDH and CK increased with the increase of the severity of admission clinical classification and the deterioration of outcome. Therefore, we propose that continuous monitoring of LDH, α-HBDH and CK indicators can warn the deterioration of COVID-19 to a certain extent, regardless of whether patients with cardiovascular diseases are combined or not, and prompt early intervention.
Keywords: LDH / COVID-19 / α-HBDH / prognostic evaluation

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