Influence of Maternal Infection and Pregnancy Complications on Cord Blood Telomere Length
Open Access
- 25 September 2021
- journal article
- research article
- Published by Hindawi Limited in Oxidative Medicine and Cellular Longevity
- Vol. 2021, 1-9
- https://doi.org/10.1155/2021/3339456
Abstract
Background. Exposure to suboptimal intrauterine environment might induce structural and functional changes that can affect neonatal health. Telomere length as an important indicator of cellular health has been associated with increased risk for disease development. Objectives. This study was aimed to examine the independent and combined effects of maternal, obstetric, and foetal factors on cord blood telomere length (TL). Methods. Pregnant women at the gestational age of 20th to 24th week who attended the antenatal clinic of a major local hospital in Hong Kong were recruited. Participants were asked to complete a questionnaire on demographics, health-related quality of life, and history of risk behaviors. Medical history including pregnancy complications and neonatal outcomes was obtained from electronic medical records of both mother and neonate. Umbilical cord blood was collected at delivery for TL determination. Results. A total of 753 pregnant women (average age: years) were recruited. The prevalence of maternal infection, anaemia, and hypertension during pregnancy was 30.8%, 30.0%, and 6.0%, respectively. The adjusted regression model displayed that maternal infection was negatively associated with cord blood TL (Keywords
This publication has 41 references indexed in Scilit:
- Tracking and fixed ranking of leukocyte telomere length across the adult life courseAging Cell, 2013
- Prenatal Stress, Telomere Biology, and Fetal Programming of Health and Disease RiskA Presentation from the European Society for Paediatric Endocrinology (ESPE) New Inroads to Child Health (NICHe) Conference on Stress Response and Child Health in Heraklion, Crete, Greece, 18 to 20 May 2012.Science Signaling, 2012
- Fetal Programming of Body Composition, Obesity, and Metabolic Function: The Role of Intrauterine Stress and Stress BiologyJournal of Nutrition and Metabolism, 2012
- Cumulative Inflammatory Load Is Associated with Short Leukocyte Telomere Length in the Health, Aging and Body Composition StudyPLOS ONE, 2011
- Genome-Wide Association Study of Relative Telomere LengthPLOS ONE, 2011
- Developmental Origins of Health and Disease: Brief History of the Approach and Current Focus on Epigenetic MechanismsSeminars in Reproductive Medicine, 2009
- Maternal psychological distress and fetal growth trajectories: The Generation R StudyPsychological Medicine, 2009
- A quantitative real-time PCR method for absolute telomere lengthBioTechniques, 2008
- Human telomere biology: pitfalls of moving from the laboratory to epidemiologyInternational Journal of Epidemiology, 2006
- A 12-Item Short-Form Health SurveyMedical Care, 1996