Lipoma, well-circumscribed tumors of mature adipose tissue, are one of the commonest encountered benign neoplasms. In the oral cavity, lipomas almost always occur in the cheek, tongue, and floor, but rarely in the lips. In this paper a 73-year old woman with lipoma in the right lower lip and cases of lipoma in the oral regions that have been reported in Japan are discussed. Her past history was diabetes mellitus and the others had no abnormalities. The specimen was a spherical, encapsulated, soft, bright-yellowish mass measuring 1.5 x 1.0cm. Microscopically, the tumor consisted of matured adipose tissue histological diagnosis of the tumor was simple lipoma. Six months postoperatively there is no sign of recurrence.