Blood cell count is not a significant predictor of survival in bladder cancer after radical cystectomy
Open Access
- 24 April 2021
- journal article
- research article
- Published by Universa Medicina in Universa Medicina
- Vol. 40 (2), 148-156
- https://doi.org/10.18051/univmed.2021.v40.151-159
Abstract
Background Radical cystectomy (RC) is the gold standard treatment for muscle-invasive bladder carcinoma. A predictive factor is needed for the aggressive approach as it could lead to overtreatment. Elevated blood cell count (BCC) markers are reported to have a significant association with poor outcomes in several types of malignancy. Neutrophil-to-lymphocyte-ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are well-known inexpensive and effective representative markers of inflammatory conditions. This study aimed to determine the BCC as a predictive factor of overall survival (OS) in patients with bladder carcinoma (BC) after RC. Methods A retrospective cohort study was conducted involving 26 patients who had undergone RC. The demographic characteristics and BCC markers such as hemoglobin (Hb). NLR, PLR and lymphocyte/monocyte ratio (LMR) were collected. The patients were categorized based on the BCC marker value (³ median and < median). Kaplan–Meier survival analysis was done to determine overall survival (OS) on BCC markers. The association between patient demographics and one-year survival was also determined using Mantel-Cox (Log-rank) method. Results Among the 26 patients, the mean age was 55.6 ± 12.9 years. On univariate analysis, none of the demographic characteristics was found to be a significant predictor of one-year and overall survival (p>0.05). Hemoglobin, NLR, PLR and LMR were not significant predictors of one-year survival and OS (p>0.05). Conclusions The BCC was not a significant predictive factor of survival in patients with bladder cancer after radical cystectomy.Keywords
This publication has 21 references indexed in Scilit:
- Identification of the best complete blood count-based predictors for bladder cancer outcomes in patients undergoing radical cystectomyBritish Journal of Cancer, 2015
- Immunity, inflammation, and cancer: an eternal fight between good and evilJCI Insight, 2015
- The neutrophil–lymphocyte ratio and its utilisation for the management of cancer patients in early clinical trialsBritish Journal of Cancer, 2015
- Predictive value of pretreatment inflammation-based prognostic scores (neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and lymphocyte-to-monocyte ratio) for invasive bladder carcinomaKorean Journal of Urology, 2015
- Prognostic Value of PLR in Various Cancers: A Meta-AnalysisPLOS ONE, 2014
- Inflammation-related DNA damage and expression of CD133 and Oct3/4 in cholangiocarcinoma patients with poor prognosisFree Radical Biology & Medicine, 2013
- Prognostic role of neutrophil-to-lymphocyte ratio in colorectal cancer: A systematic review and meta-analysisInternational Journal of Cancer, 2013
- A derived neutrophil to lymphocyte ratio predicts survival in patients with cancerBritish Journal of Cancer, 2012
- Inflammation-induced protein carbonylation contributes to poor prognosis for cholangiocarcinomaFree Radical Biology & Medicine, 2012
- Hallmarks of Cancer: The Next GenerationCell, 2011