Effective dose of propolis extract combined with bovine bone graft on the number of osteoblasts and osteoclasts in tooth extraction socket preservation
Open Access
- 31 March 2020
- journal article
- Published by Universitas Airlangga in Dental Journal (Majalah Kedokteran Gigi)
- Vol. 53 (1), 40-44
- https://doi.org/10.20473/j.djmkg.v53.i1.p40-44
Abstract
Background: Maintaining a good ridge is required during prosthodontic treatment. Hence, adequate alveolar bone support is considered an important factor in pursuing successful dentures. Propolis extract combined with bovine bone graft is a recent and innovative material in the process of socket preservation, as the caffeic acid phenethyl ester (CAPE) it contains can suppress the inflammatory process. Purpose: This study aims to determine the effective dose of propolis extract combined with bovine bone graft on the number of osteoblasts and osteoclasts in socket preservation. Methods: Twenty-eight Cavia cobaya animals were divided into four groups of seven. Group I was given 25 grams of PEG, while Group II were given a propolis extract at a dose of 0.5% combined with bovine bone graft. Group III were given a propolis extract at a dose of 1% combined with bovine bone graft and Group IV were given a propolis extract at a dose of 2% combined with bovine bone graft. On day 30, the lower incisor of each subject was extracted and induced with PEG and propolis (dose 0.5%, 1%, 2%). Histopathological examinations of osteoblasts and osteoclasts were measured with a 400x magnification light microscope. One-way ANOVA and Tukey HSD tests were performed to analyse data statistically. Results: The propolis extract combined with bovine bone graft not only increased the number of osteoblasts but also reduced the number of osteoclasts. The most effective dose for the propolis extract combined with bovine bone graft was 2%. Conclusion: The propolis extract combined with bovine bone graft could be effective in tooth extraction socket preservation at a dose of 2%.Keywords
This publication has 11 references indexed in Scilit:
- The effect of a combination of propolis extract and bovine bone graft on the quantity of fibroblasts, osteoblasts and osteoclasts in tooth extraction socketsDental Journal (Majalah Kedokteran Gigi), 2019
- Effect of mangosteen peel extract combined with demineralized freezed-dried bovine bone xenograft on osteoblast and osteoclast formation in post tooth extraction socketDental Journal (Majalah Kedokteran Gigi), 2016
- Strategies for alveolar ridge reconstruction and preservation for implant therapyJournal of Prosthodontic Research, 2015
- Surgical techniques for maxillary bone grafting - literature reviewRevista do Colégio Brasileiro de Cirurgiões, 2014
- Molecular Basis of Requirement of Receptor Activator of Nuclear Factor κB Signaling for Interleukin 1-mediated OsteoclastogenesisOnline Journal of Public Health Informatics, 2012
- Effects of Propolis on Fracture Healing: An Experimental StudyPhytotherapy Research, 2011
- Propolis inhibits osteoclast maturationDental Traumatology, 2009
- Caffeic acid phenethyl ester, an active component of honeybee propolis attenuates osteoclastogenesis and bone resorption via the suppression of RANKL‐induced NF‐κB and NFAT activityJournal of Cellular Physiology, 2009
- Implant Success in Distracted Bone Versus Autogenous Bone-Grafted SitesJournal of Oral Implantology, 2009
- Caffeic acid phenethyl ester inhibits osteoclastogenesis by suppressing NFκB and downregulating NFATc1 and c-FosInternational Immunopharmacology, 2009