The aim of this study is to investigate the agreement between the thyroid image reporting and data systems (TI-RADS) classification and the Bethesda scoring in adults with thyroid nodules and to evaluate the effectiveness of our clinic in the management of thyroid nodules. In this prospective study, in which the analyzes of the patients who applied to the Interventional Radiology Department of our hospital for fine needle aspiration biopsy due to thyroid nodule were analyzed, 59 patients were included between January 1, 2020 and June 1, 2020. Sonographic features (composition, echogenicity, shape, margin, and echogenic foci) of all nodules were recorded for TI-RADS scoring before biopsy and TI-RADS scoring was performed by the radiologist. It was then the results compared with the Bethesda scoring, which is the cytological classification. A total of 59 patients (n=43; 72.9% female and, n=16; 27.1% male) were analyzed. Of the biopsied nodules, 31 (52.5%) were localized in the right lobe and 28 (47.5%) in the left lobe. The mean longest diameter of the nodules was 35.9±13.9 mm (range, 13-70 mm). The TI-RADS category was also significantly higher in those with larger nodule diameters (p=0.026). There was moderate agreement between both scorings (kappa value=0.406 and p<0.001). There were 7 (11.9%) patients with TI-RADS ≥ 4 and 10 (16.9%) patients classified as Bethesda ≥ 4. Thyroid nodules reported as highly suspected of malignancy (TIRADS ≥ 4) had good agreement with Bethesda scoring (Kappa value= 0.658 and p<0.001). According to the findings of our study, there is a moderate agreement between TI-RADS scoring and Bethesda. However, the rate of compliance was increasing in nodules classified as malignant nodules (TI-RADS ≥4).