Comparison of liquid-based cytology (CellPrepPlus) and conventional smears in pancreaticobiliary disease
Open Access
- 1 September 2018
- journal article
- research article
- Published by Korean Association of Internal Medicine in The Korean Journal of Internal Medicine
- Vol. 33 (5), 883-892
- https://doi.org/10.3904/kjim.2016.173
Abstract
Background/Aims: Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) and brushing cytology are used worldwide to diagnose pancreatic and biliary malignant tumors. Liquid-based cytology (LBC) has been developed and it is currently used to overcome the limitations of conventional smears (CS). In this study, the authors aimed to compare the diagnostic value of the CellPrepPlus (CP; Biodyne) LBC method with CS in samples obtained using EUS-FNA and brushing cytology. Methods: This study prospectively enrolled 75 patients with pancreatic or biliary lesions from June 2012 to October 2.013. For cytological analyses, including inadequate specimens, benign and atypical were further classified into benign, and suspicious and malignant were subcategorized as malignant. Sensitivity, specificity, accuracy, and positive predictive values (PPV) and negative predictive values (NPV) were evaluated. Results: In the EUS-FNA based cytological analysis of pancreatic specimens, CP had a sensitivity of 60.7%; specificity, 100%; accuracy, 77.1%; PPV, 100%; and NPV, 64.5%. CS had a sensitivity of 85.7%; specificity, 100%; accuracy, 91.7%; PPV, 100%; and NPV, 83.3%. In the brushing cytology based analysis of biliary specimens, CP had sensitivity of 53.1%; specificity, 100%; accuracy, 54.5%; PPV, 100%; and NPV, 6.3%. CS had a sensitivity of 78.1%; specificity, 100%; accuracy, 78.8%; PPV, 100%; and NPV, 12.5%. Conclusions: Our study found that CP had a lower sensitivity because of low cellularity compared with CS. Therefore, CP (LBC) has a lower diagnostic accuracy for pancreatic EUS-FNA based and biliary brush cytology based analyses compared with CS.Keywords
This publication has 16 references indexed in Scilit:
- EUS-guided FNA for diagnosis of solid pancreatic neoplasms: a meta-analysisGastrointestinal Endoscopy, 2012
- CellprepPlus® Liquid-based Smear in Sono-guided Thyroid Fine Needle Aspiration: A Comparison of Conventional Method and CellprepPlus® Liquid-based CytologyThe Korean Journal of Pathology, 2011
- Improving cellularity and quality of liquid-based cytology slides processed from pancreatobiliary tract brushingsDiagnostic Cytopathology, 2010
- A prospective study comparing rapid assessment of smears and ThinPrep® for endoscopic ultrasound-guided fine-needle aspiratesEndoscopy, 2010
- Comparison of Cytologic Evaluation between Conventional Method and CellprepPlus® Liquid-Based Cytology in Body FluidThe Korean Journal of Pathology, 2009
- Liquid-Based Cytology in Gynecologic CytologyThe Korean Journal of Pathology, 2009
- Biliary brush cytology: Factors associated with positive yields on biliary brush cytologyWorld Journal of Gastroenterology, 2008
- Pancreatic and bile duct brushing cytology in 1000 casesCancer, 2006
- ERCP‐directed brush cytology prepared by the Thinprep® method: test performance and morphology of 149 casesCytopathology, 2004
- Comparison of ThinPrep and conventional smears in detecting carcinoma in bile duct brushingsCancer, 2003