Could a specific ACE2 activator drug improve the clinical outcome of SARS-CoV-2? A potential pharmacological insight
- 25 July 2020
- journal article
- editorial
- Published by Taylor & Francis Ltd in Expert Review of Clinical Pharmacology
- Vol. 13 (8), 807-811
- https://doi.org/10.1080/17512433.2020.1798760
Abstract
It has been known since the first identified SARS epidemic that the receptor critical for SARS-CoV entry into host cells is the angiotensin-converting enzyme 2 (ACE2), an important actor on renin-a...Keywords
Funding Information
- CNPq
- Research Foundation for the State of Piauí—FAPEPI
This publication has 40 references indexed in Scilit:
- Prediction of Off-Target Effects on Angiotensin-Converting Enzyme 2SLAS Discovery, 2011
- Evidence that TMPRSS2 Activates the Severe Acute Respiratory Syndrome Coronavirus Spike Protein for Membrane Fusion and Reduces Viral Control by the Humoral Immune ResponseJournal of Virology, 2011
- TACE antagonists blocking ACE2 shedding caused by the spike protein of SARS-CoV are candidate antiviral compoundsAntiviral Research, 2010
- Angiotensin-converting enzyme 2 in acute respiratory distress syndromeCellular and Molecular Life Sciences, 2007
- Tumor Necrosis Factor-α Convertase (ADAM17) Mediates Regulated Ectodomain Shedding of the Severe-acute Respiratory Syndrome-Coronavirus (SARS-CoV) Receptor, Angiotensin-converting Enzyme-2 (ACE2)Online Journal of Public Health Informatics, 2005
- A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus–induced lung injuryNature Medicine, 2005
- Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS‐CoV) in SARS patients: implications for pathogenesis and virus transmission pathwaysThe Journal of Pathology, 2004
- Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesisThe Journal of Pathology, 2004
- Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirusNature, 2003
- Pharmacology of diminazene: a reviewActa Tropica, 1993