Aims: Recombinant proteins rP2 has demonstrated biological activity in inflammation by acting on the recruitment of leukocytes and by inducing phagocytosis, also modulating the processes of angiogenesis and fibrogenesis in different experimental models. In this study we evaluated the effects of the recombinant protein rP21 from Trypanosama cruzi in cutaneous wounds. Study Design: The wounds were induced on the back of mice and treated with rP21 at 1 µg/mL and 50 µg/mL concentration, for 3 and 7 days. Study Location and Duration: Institute of Biomedical Sciences and Animal Breeding Network and Rodents of the Federal University of Uberlândia, between February 2015 and February 2016. Methodology: The contraction time of wound, inflammatory cell activities (neutrophils and macrophages), angiogenesis and local collagen density were evaluated. Sample: Wound induction was performed on 64 male BALB / c mice approximately 9 weeks old. Results: Wounds treated with rP21 showed less closure time, in addition to exhibiting greater neutrophil activity in the initial phasis, which was reduced simultaneously with the increased macrophage activity. The rP21 also performed pro-angiogenic and pro-fibrogenic activity in this study model. Conclusion: These results demonstrate for the first time the biological potential of rP21 in accelerating skin tissue repair.