Insect Gut Regeneration
- 26 July 2021
- journal article
- research article
- Published by Cold Spring Harbor Laboratory in Cold Spring Harbor Perspectives in Biology
- Vol. 14 (2), a040915
- https://doi.org/10.1101/cshperspect.a040915
Abstract
In adult insects, as in vertebrates, the gut epithelium is a highly regenerative tissue that can renew itself rapidly in response to changing inputs from nutrition, the gut microbiota, ingested toxins, and signals from other organs. Because of its cellular and genetic similarities to the mammalian intestine, and its relevance as a target for the control of insect pests and disease vectors, many researchers have used insect intestines to address fundamental questions about stem cell functions during tissue maintenance and regeneration. In Drosophila, where most of the experimental work has been performed, not only are intestinal cell types and behaviors well characterized, but numerous cell signaling interactions have been detailed that mediate gut epithelial regeneration. A prevailing model for regenerative responses in the insect gut invokes stress sensing by damaged enterocytes (ECs) as a principal source for signaling that activates the division of intestinal stem cells (ISCs) and the growth and differentiation of their progeny. However, extant data also reveal alternative mechanisms for regeneration that involve ISC-intrinsic functions, active culling of healthy epithelial cells, enhanced EC growth, and even cytoplasmic shedding by infected ECs. This article reviews current knowledge of the molecular mechanisms involved in gut regeneration in several insect models (Drosophila and Aedes of the order Diptera, and several Lepidoptera).This publication has 193 references indexed in Scilit:
- Dpp Signaling Determines Regional Stem Cell Identity in the Regenerating Adult Drosophila Gastrointestinal TractCell Reports, 2013
- Morphological and Molecular Characterization of Adult Midgut Compartmentalization in DrosophilaCell Reports, 2013
- Role of UPR Pathway in Defense Response of Aedes aegypti against Cry11Aa Toxin from Bacillus thuringiensisInternational Journal of Molecular Sciences, 2013
- Stem cells and lineages of the intestine: a developmental and evolutionary perspectiveWilhelm Roux' Archiv für Entwicklungsmechanik der Organismen, 2012
- Altered Modes of Stem Cell Division Drive Adaptive Intestinal GrowthCell, 2011
- Stem Cell Dynamics in Response to Nutrient AvailabilityCurrent Biology, 2010
- Warts and Yorkie Mediate Intestinal Regeneration by Influencing Stem Cell ProliferationCurrent Biology, 2010
- JAK–STAT is restrained by Notch to control cell proliferation of the Drosophila intestinal stem cellsJournal of Cellular Biochemistry, 2010
- Cytokine/Jak/Stat Signaling Mediates Regeneration and Homeostasis in the Drosophila MidgutCell, 2009
- The Molecular Cloning and Characterization of Drosophila melanogaster Myosin-IA and Myosin-IBJournal of Molecular Biology, 1994