新型冠状病毒(COVID-19)肺炎疫情全球流行，不仅对人民群众的身体健康和生命安全造成了重大损害，而且对人民群众的日常生活和疾病诊治产生了严重影响。作为疫情后方非定点医院的普通外科，如何既有效预防院内交叉感染、避免聚集性疫情事件发生，又积极开展危急重症患者手术救治，是我们当前面临的严峻考验。阑尾周围脓肿作为一种急腹症，在保守治疗无效情况下，传统手术方式是穿刺置管或切开引流、二期切除阑尾。本文结合一例60岁老年患者的腹腔镜阑尾周围脓肿手术治疗体会，探讨COVID-19疫情期间的隔离防护及腹腔镜阑尾周围脓肿术式选择，以期为疫情期间普通外科危急重症救治提供借鉴。 The global pandemic of coronavirus disease 2019 (COVID-19) pneumonia is posing a great threat to people’s health and life, and has seriously affected people’s daily life and diagnosis and treatment of other diseases. As a department of a non-appointed COVID-19 accepting hospital in the rear of the epidemic situation, general surgery is facing on a serious challenge of how to effectively prevent nosocomial infection and avoid the occurrence of clustered epidemic events, and actively carry out emergency surgical treatment for critically-ill patients. Periappendiceal abscess is a kind of acute abdomen. In the case of ineffective conservative treatment, the traditional surgical method is puncture tube or incision drainage, and secondary appendectomy. Combined with the experience of laparoscopic surgery for periappendiceal abscess in a 60-year-old patient, this paper explores the full process of epidemic protection and the selection of surgical methods for laparoscopic periappendiceal abscess, so as to provide reference for emergency treatment and effective epidemic protection of general surgery during the COVID-19 epidemic.