IMPACT OF PHARMACIST LED PHARMACEUTICAL CARE ON PATIENT MEDICATION THERAPY USING PROMPT-QOL IN TERTIARY CARE HOSPITAL: A RANDOMIZED CONTROLLED TRIAL

Abstract
Background: Pharmacists play vital role in health care system; they help to prevent medication errors. At discharge from health care facility 20% to 70% patients have at least one medication discrepancy. Pharmacist has direct impact on reducing readmission in hospitals as well as emergency visits. There is substantial reduction of 67%, 28% and 19% in adverse drug event-related to hospital revisits, (ED) visits and hospital readmissions. Objectives: To determine the Impact of pharmacist led pharmaceutical care on patient medication therapy by comparing PROMPT-QOL between pharmaceutical care (PC) patients and usual care (UC) patients. Also to compare the characteristics of participants between PC and UC groups. Methods: A randomized controlled trial was conducted at tertiary care hospital in Pakistan, Rawalpindi from May to October 2020.A total of 300 patients were randomly allocated into UC (N = 150) and PC (N = 150) groups respectively, the follow up period was one month. Results: Independent Sample t-test results showed that post intervention in pharmaceutical care group had significantly higher mean changes in 8 Domains of PROMP- QOL than in usual care group. The Domains were MDI (Medicine and Disease Information), SME(Satisfaction of Medicine Effectiveness), IMS (Impacts of medicines and Side effects), PIMU (Psychological Impacts of Medication Use), CON (Convenience), AA (Availability and Accessibility), TRHC (Therapeutic Relationships with Health care providers) and OQOL (Overall quality of life) with p-value Conclusions: Pharmacist oriented pharmaceutical care could improve patient medication therapy related to quality of life hence there is a need of proper pharmacist counseling room in at least tertiary care hospitals so that patient can better understand medication to improve quality of life. Eight domains of PROMPT-QOL showed significant results and were sufficient to assess humanistic impact of pharmaceutical care.