The effect of hepatitis B vaccination after five years on an entire population in an insular region of Southeast China
- 14 December 2020
- journal article
- Published by Taylor & Francis Ltd in Human Vaccines & Immunotherapeutics
- Vol. 17 (5), 1530-1535
- https://doi.org/10.1080/21645515.2020.1814096
Abstract
Prevalence of hepatitis B (HB) remains high among adults in insular regions of southeast China. To address this issue, large-scale HB vaccination was implemented in Putuo County of Zhoushan City in 2013. To examine the effects of this large-scale HB vaccination, a cross-sectional serological survey was conducted on two isolated islands, Putuo (intervention group) and Dinghai (control group) Counties of Zhoushan City in southeastern China five years later. The data showed lower prevalence of HBsAg and negative results for all HBV markers in the intervention group compared to the control group (4.2% and 6.0%, 20.8% and 33.0%), while the positive rate for anti-HBs and only anti-HBs were higher (68.4% and 53.4%, 47.9% and 34.3%). Therefore, large-scale adult HB vaccination could lower the HB epidemic level. However, the proportion of susceptible people who were negative for all HBV markers remained high. Hence, several additional measures to limit the spread of HBV should be taken by the government.Keywords
Funding Information
- National Scientific and Technological Major (2018ZX10715014, No. 2017ZX10105001, No. 2013ZX10004-904, and No. 2014ZX10004008)
This publication has 14 references indexed in Scilit:
- Prevention of Chronic Hepatitis B after 3 Decades of Escalating Vaccination Policy, ChinaEmerging Infectious Diseases, 2017
- Responses to hepatitis B vaccine in isolated anti-HBc positive adultsHuman Vaccines & Immunotherapeutics, 2016
- Healthy adult vaccination: An urgent need to prevent hepatitis B in ChinaHuman Vaccines & Immunotherapeutics, 2015
- The global burden of liver disease: The major impact of ChinaJournal of Hepatology, 2014
- Update on epidemiology of hepatitis B and C in ChinaJournal of Gastroenterology and Hepatology, 2013
- Prevalence of Hepatitis B in Insular Regions of Southeast China: A Community-Based StudyPLOS ONE, 2013
- Global epidemiology of hepatitis B virus infection: New estimates of age-specific HBsAg seroprevalence and endemicityVaccine, 2012
- Prevalence of hepatitis B in the southeast of ChinaEuropean Journal of Gastroenterology & Hepatology, 2011
- Epidemiological serosurvey of Hepatitis B in China—Declining HBV prevalence due to Hepatitis B vaccinationVaccine, 2009
- Assessment of Total Economic Burden of Chronic Hepatitis B (CHB)-Related Diseases in Beijing and Guangzhou, ChinaValue in Health, 2009