Vaccines are one of the most significant innovations of modern science. Worldwide, millions of lives are saved each year by the vaccine. Vaccine hesitancy, which represents the refusal to receive vaccines when vaccination services are available and reachable, is a major obstacle to global health. While vaccine hesitancy has been present for many years, its damaging effects are likely to be more evident during the COVID-19 pandemic than ever before. This study aimed to find out common causes of vaccine hesitancy, assess COVID-19 vaccination acceptance rates worldwide, and present the approaches by which vaccine hesitancy rate can be reduced. This study revealed though vaccine hesitancy is a worldwide phenomenon, the causes differ from country to country or reign. More studies are needed to address COVID-19 vaccine hesitancy, especially in the Middle and South America, the Middle East and North Africa, Central Asia, Sub-Saharan Africa, Eastern Europe. The leading causes of COVID-19 vaccine hesitancy are found lack of confidence towards the government or pharmaceutical companies, less concern about the outcome of SARS-CoV-2 infection, and shortage of supply of different types of COVID-19 vaccines. Healthcare personnel and social media play an essential role in addressing vaccine hesitancy. Convincing the general population about the safety and effectiveness of COVID-19 vaccines, the consequence of being unvaccinated, and the delivery of free vaccines in an easily accessible way can reduce vaccine hesitancy rate.