Acquired Long QT Syndrome: A Review of the Literature
Open Access
- 27 February 2020
- journal article
- review article
- Published by Asploro Open Access Publications in Asploro Journal of Biomedical and Clinical Case Reports
- Vol. 3 (1), 67-70
- https://doi.org/10.36502/2020/asjbccr.6188
Abstract
The QT interval represents the duration of ventricular depolarization and repolarization. It is measured from the beginning of the QRS complex to the end of the T wave. Prolongation of the QT interval may be congenital or acquired. This increases the risk of polymorphic ventricular tachycardia (i.e torsades de pointes) and cardiac arrest. To increase the awareness of this life-threatening phenomenon I outline an illustrative case in which acquired prolongation of the QT interval due to electrolyte derangement and administration of ciprofloxacin resulted in cardiac arrest due to torsade de pointes. Management of a patient with a long QT syndrome includes Immediate cessation of drugs that prolong the QT interval; cardiac monitoring, serial 12 lead ECGs and transthoracic echocardiography; measurement of serum electrolytes; intravenous potassium replacement; intravenous magnesium replacement; beta-blockade. Causes of acquired prolongation of the QT interval are common in critically ill patients. It is important to recognize this and consider screening with 12 lead ECG to reduce the risk of life-threatening ventricular arrhythmias.Keywords
This publication has 8 references indexed in Scilit:
- Drug-induced QT interval prolongation: mechanisms and clinical managementTherapeutic Advances in Drug Safety, 2012
- Oxford Case Histories in CardiologyPublished by Oxford University Press (OUP) ,2011
- Antimicrobial-Associated QT Interval Prolongation: Pointes of InterestClinical Infectious Diseases, 2006
- Advances in congenital long QT syndromeCurrent Opinion in Pediatrics, 2006
- Mechanisms underlying arrhythmogenesis in long QT syndromeJournal of Electrocardiology, 2005
- Congenital and Acquired Long QT SyndromeCardiology in Review, 2004
- Allelic Variants in Long-QT Disease Genes in Patients With Drug-Associated Torsades de PointesJournal of the American College of Cardiology, 2002
- Low Penetrance in the Long-QT SyndromeJournal of the American College of Cardiology, 1999