Histone deacetylases and cancer
Top Cited Papers
- 27 August 2012
- journal article
- review article
- Published by Wiley in Molecular Oncology
- Vol. 6 (6), 579-589
- https://doi.org/10.1016/j.molonc.2012.07.003
Abstract
Reversible acetylation of histone and non-histone proteins is one of the most abundant post-translational modifications in eukaryotic cells. Protein acetylation and deacetylation are achieved by the antagonistic actions of two families of enzymes, histone acetyltransferases (HATs) and histone deacetylases (HDACs). Aberrant protein acetylation, particularly on histones, has been related to cancer while abnormal expression of HDACs has been found in a broad range of cancer types. Therefore, HDACs have emerged as promising targets in cancer therapeutics, and the development of HDAC inhibitors (HDIs), a rapidly evolving area of clinical research. However, the contributions of specific HDACs to a given cancer type remain incompletely understood. The aim of this review is to summarize the current knowledge concerning the role of HDACs in cancer with special emphasis on what we have learned from the analysis of patient samples. (c) 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.Keywords
Funding Information
- Spanish Ministry of Science and Innovation-MICIIN
- Spanish Ministry of Economy and competitivenes-MINICO
- Marie Curie International Re-integration (FP7-PEOPLE-2007-4-3-IRG)
This publication has 120 references indexed in Scilit:
- Combination therapy for hepatocellular carcinoma: Additive preclinical efficacy of the HDAC inhibitor panobinostat with sorafenibJournal of Hepatology, 2012
- Class IIb HDAC6 regulates endothelial cell migration and angiogenesis by deacetylation of cortactinThe EMBO Journal, 2011
- SAHA shows preferential cytotoxicity in mutant p53 cancer cells by destabilizing mutant p53 through inhibition of the HDAC6-Hsp90 chaperone axisCell Death & Differentiation, 2011
- Regulation of chromatin by histone modificationsCell Research, 2011
- HDAC expression and clinical prognosis in human malignanciesCancer Letters, 2009
- Histone deacetylase 11 regulates oligodendrocyte‐specific gene expression and cell development in OL‐1 oligodendroglia cellsGlia, 2008
- Nutrient-Sensitive Mitochondrial NAD+ Levels Dictate Cell SurvivalCell, 2007
- Histone deacetylase-1 and -3 protein expression in human breast cancer: a tissue microarray analysisBreast Cancer Research and Treatment, 2005
- Upregulation and Nuclear Recruitment of HDAC1 in Hormone Refractory Prostate CancerThe Prostate, 2004
- The language of covalent histone modificationsNature, 2000