The performance appraisal of specialist nurses is an important part of hospital human resource management, and it is also a necessary path to promote the professional development of specialist nurses. Based on the analysis and discussion of the framework design of the performance appraisal system for specialist nurses, this paper studies and discusses the design safeguard measures of the performance appraisal system for specialist nurses, in order to effectively improve the scientific performance of the specialist nurses’ performance appraisal system. Level, lay a good foundation for the improvement of the professional nursing staff's work level and the sustainable development of the hospital.