Comparative study of hospitalized children with acute respiratory distress syndrome caused by SARS-CoV-2 and influenza virus
Open Access
- 4 May 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in BMC Infectious Diseases
- Vol. 21 (1), 1-9
- https://doi.org/10.1186/s12879-021-06068-w
Abstract
Since the outbreak of coronavirus disease 2019 in December 2019, more than 8 million cases have occurred worldwide as of June 16, 2020. However, it is important to distinguish COVID-19 from other respiratory infectious diseases, such as influenza. Here, we comparatively described the clinical characteristics of children with COVID-19 and paediatric patients with influenza. In this retrospective, single-centre study, we reviewed the electronic medical records of 585 paediatric patients with COVID-19 or influenza in Wuhan Children’s Hospital, China. Clinical and epidemiological characteristics, laboratory findings, and clinical outcomes were comparatively analysed. The median ages were 6.96 years (IQR, 2–10.81) for children with confirmed COVID-19, 2.67 years (IQR, 1.03–15.25) for those with influenza A and 3.67 years (IQR, 1.62–5.54) for those with influenza B. Fever was a symptom in 84 (34.7%) COVID-19 cases, 132 (70.21%) influenza A cases and 111 (74.50%) influenza B cases. The median length of stay (LOS) was 11 (8–15) days for paediatric COVID-19 patients, 4 (3–6) days for influenza A patients and 5 (3–6) days for influenza B patients. Twenty-six (13.98%) influenza A patients and 18 (12.59%) influenza B patients presented with decreased white blood cell counts, while 13 (5.33%) COVID-19 patients presented with decreased white blood cell counts. Eight (3.28%) COVID-19 patients, 23 (12.71%) influenza A patients and 21 (14.79%) influenza B patients experienced lymphocytopenia. Acute cardiac injury occurred in 18 (7.29%) COVID-19 patients, while 37 (19.68%) influenza A and 27 (18.12%) influenza B patients had acute cardiac injury. In this study, the illnesses of children with COVID-19 were demonstrated to be less severe than those of paediatric patients with influenza, and COVID-19 patients had milder illness and fewer complications.Funding Information
- Hubei Key Laboratory of Animal Nutrition and Feed Science (2017CFB412)
- Nature Science Foundation of Hubei Province (2017CFB633)
- Health Research Project of Hubei Province (WJ2019M166)
This publication has 20 references indexed in Scilit:
- Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in ChinaJAMA, 2020
- A Novel Coronavirus from Patients with Pneumonia in China, 2019The New England Journal of Medicine, 2020
- Human-to-Human Transmission of Influenza A(H3N2) Virus with Reduced Susceptibility to Baloxavir, Japan, February 2019Emerging Infectious Diseases, 2019
- Middle East respiratory syndrome coronavirus disease is rare in children: An update from Saudi ArabiaWorld Journal of Clinical Pediatrics, 2016
- Middle East respiratory syndrome coronavirus in childrenSciVee, 2015
- Middle East Respiratory Syndrome Coronavirus Disease in ChildrenThe Pediatric Infectious Disease Journal, 2014
- Viral pneumoniaThe Lancet, 2011
- Household Transmission of 2009 Pandemic Influenza A (H1N1) Virus in the United StatesThe New England Journal of Medicine, 2009
- Clinical presentations and outcome of severe acute respiratory syndrome in childrenThe Lancet, 2003