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The phosphatase PAC1 acts as a T cell suppressor and attenuates host antitumor immunity

Dan Lu, Liang Liu, Yizhe Sun, Jia Song, Qi Yin, Guangze Zhang, Fang Qi, Zixi Hu, Zeliang Yang, Zhe Zhou, Ying Hu, Lianhai Zhang, Jiafu Ji, Xuyang Zhao , Yan Jin, Michael A. McNutt, Yuxin Yin
Published: 13 January 2020
Nature Immunology , Volume 21, pp 287-297; doi:10.1038/s41590-019-0577-9

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Keywords: immunotherapy / chromatin / Function / epigenetic / antitumor / Remodeling / Pac1 / effector T cells / Exhausted

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