Changes in the Lipid Peroxidation—Antioxidant Protection System in Women with Ovarian Hyperandrogenism at Different Periods of Reproductive Age
- 16 January 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Bulletin of Experimental Biology and Medicine
- Vol. 170 (3), 308-311
- https://doi.org/10.1007/s10517-021-05057-y
Abstract
We studied changes in LPO processes and antioxidant protection system in women with ovarian hyperandrogenism at various periods of reproductive age 18-45 years. An age-related decrease in total antioxidant activity and accumulation of secondary LPO products, ketodiens and coupled trienes, were found; these changes were accompanied by an increase in the level of superoxide dismutase and a decrease in the concentrations of reduced glutathione, α-tocopherol, and retinol. Women of early reproductive age (18-35 years) with hyperandrogenism were characterized by increased content of oxidized glutathione accompanied by a decrease in the level of α-tocopherol and retinol in comparison with the control group. In women of late reproductive age (35-45 years) with hyperandrogenism, increased superoxide dismutase activity in comparison with the control group was revealed.Keywords
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