Anthelmintic agents: vermicide and vermifuge
- 6 May 2022
- journal article
- Published by Heighten Science Publications Corporation in Insights in Biology and Medicine
- Vol. 6 (1), 001-008
- https://doi.org/10.29328/journal.ibm.1001020
Abstract
Helminthiasis is also known as worm infection, is any macroparastic disease of humans and other animals in which a part of the body is infected with parasitic worms known as helminths. Anthelmintic agents are medicines that used for treatment and inhibition of parasitic infections caused by helminths; which involve both flat worms, such as, flukes and tapeworms and round worms, such as, nematodes. Anthelmintics are categorized into groups depending on the basis of their identical chemical structure and mode of action. Thiabendazole, mebendazole, and albendazole belong to benzimidazoles group of antihelmenthic medicines. From benzimidazoles group of antihelmenthic, thiabendazole was first discovered in 1961 and already a mentioned number of more benzamidazoles were interpolated as wide spectrum anthelmintics. Praziquantel has a particular effect on the enveloping layer of trematodes and increases permeability of calcium ion influx leading to uncontrolled muscle contraction and paralysis. Praziquantel has a particular toxic effect on schistosome parasites, where its mode of action has been resulted more extensively than in cestodes. Coadministration of mebendazole with CYP450 inhibitors medications such as cimetidine, ketoconazole and etc may be increases plasma levels of mebendazole, by extending the half-life and decreasing plasma clearance.Keywords
This publication has 38 references indexed in Scilit:
- Development of drugs based on imidazole and benzimidazole bioactive heterocycles: recent advances and future directionsMedicinal Chemistry Research, 2015
- Anthelmintic drugs and nematicides: studies in Caenorhabditis elegansWormBook, 2014
- Present-day anthelmintics and perspectives on future new targetsZeitschrift für Parasitenkunde, 2014
- Treatment of Giardiasis: Current Status and Future DirectionsCurrent Infectious Disease Reports, 2014
- A randomized, double-blind, multicenter clinical trial on the efficacy of ivermectin against intestinal nematode infections in ChinaActa Tropica, 2008
- Pharmacology of N ‐, L ‐, and B ‐subtypes of nematode nAChR resolved at the single‐channel level in Ascaris suumThe FASEB Journal, 2006
- Cestode infection: immunological considerations from host and tapeworm perspectives.Published by CABI Publishing ,2006
- Drug resistance and neurotransmitter receptors of nematodes: recent studies on the mode of action of levamisoleParasitology, 2005
- Ca 2+ signalling, voltage-gated Ca 2+ channels and praziquantel in flatworm neuromusculatureParasitology, 2005
- Is praziquantel therapy safe during pregnancy?Transactions of the Royal Society of Tropical Medicine and Hygiene, 2004