Early Transformation to Classic Hodgkin Lymphoma in a Chemotherapy-naïve Chronic Lymphocytic Leukemia Patient upon Initial Treatment with Ibrutinib
Open Access
- 15 October 2021
- journal article
- research article
- Published by Japanese Society of Internal Medicine in Internal Medicine
- Vol. 60 (20), 3305-3308
- https://doi.org/10.2169/internalmedicine.6979-20
Abstract
A 71-year-old woman with a four-year history of chronic lymphocytic leukemia (CLL) received ibrutinib as initial treatment due to progressive anemia and thrombocytopenia. Eleven months after the start of the treatments, although her cytopenia had ameliorated, she developed classic Hodgkin lymphoma, a rare form of Richter's transformation. She was successfully treated with two courses of adriamycin, vinblastin, bleomycin and dacarbazine followed by radiotherapy. In general, several clinical, genetic and molecular factors are associated with Richter's transformation. In addition, our present case suggested that ibrutinib could be a potential risk factor for Richter's transformation in CLL patients.Keywords
This publication has 17 references indexed in Scilit:
- Emergence of Bruton's tyrosine kinase‐negative Hodgkin lymphoma during ibrutinib treatment of chronic lymphocytic leukaemiaEuropean Journal of Haematology, 2017
- Hodgkin Lymphoma Transformation of Chronic Lymphocytic Leukemia Under Ibrutinib Therapy: Chance Association or Therapy-related?Anticancer Research, 2017
- Clonal evolution leading to ibrutinib resistance in chronic lymphocytic leukemiaBlood, 2017
- Phosphatidylinositol 3-kinase δ blockade increases genomic instability in B cellsNature, 2017
- Ibrutinib as Initial Therapy for Patients with Chronic Lymphocytic LeukemiaThe New England Journal of Medicine, 2015
- Etiology of Ibrutinib Therapy Discontinuation and Outcomes in Patients With Chronic Lymphocytic LeukemiaJAMA Oncology, 2015
- Hodgkin transformation of chronic lymphocytic leukemia: Incidence, outcomes, and comparison to de novoHodgkin lymphomaAmerican Journal of Hematology, 2015
- Targeting BTK with Ibrutinib in Relapsed Chronic Lymphocytic LeukemiaThe New England Journal of Medicine, 2013
- Hodgkin lymphoma as Richter transformation in chronic lymphocytic leukaemia: a retrospective analysis of world literatureBritish Journal of Haematology, 2011
- Hodgkin transformation of chronic lymphocytic leukemiaCancer, 2006