An age-downregulated ribosomal RpS28 protein variant regulates the muscle proteome
Open Access
- 11 May 2021
- journal article
- research article
- Published by Oxford University Press (OUP) in G3 Genes|Genomes|Genetics
- Vol. 11 (7)
- https://doi.org/10.1093/g3journal/jkab165
Abstract
Recent evidence indicates that the composition of the ribosome is heterogeneous and that multiple types of specialized ribosomes regulate the synthesis of specific protein subsets. In Drosophila, we find that expression of the ribosomal RpS28 protein variants RpS28a and RpS28-like preferentially occurs in the germline, a tissue resistant to aging and that it significantly declines in skeletal muscle during aging. Muscle-specific overexpression of RpS28a at levels similar to those seen in the germline decreases early mortality and promotes the synthesis of a subset of proteins with known anti-aging roles, some of which have preferential expression in the germline. These findings indicate a contribution of specialized ribosomal proteins to the regulation of the muscle proteome during aging.Keywords
Funding Information
- American Federation for Aging Research
- Glenn Foundation for Medical Research
- Ellison Medical Foundation
- American Parkinson Disease Association
- Hartwell Foundation
- National Institute on Aging
- NIH (R01AG055532, R56AG063806)
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