New Search

Export article
Open Access

An age-downregulated ribosomal RpS28 protein variant regulates the muscle proteome

Jianqin Jiao, Kanisha Kavdia, Vishwajeeth Pagala, Lance Palmer, David Finkelstein, Yiping Fan, Junmin Peng,
G3 Genes|Genomes|Genetics ; doi:10.1093/g3journal/jkab165

Abstract: Recent evidence indicates that the composition of the ribosome is heterogeneous and that multiple types of specialized ribosomes regulate the synthesis of specific protein subsets. In Drosophila, we find that expression of the ribosomal RpS28 protein variants RpS28a and RpS28-like preferentially occurs in the germline, a tissue resistant to aging, and that it significantly declines in skeletal muscle during aging. Muscle-specific overexpression of RpS28a at levels similar to those seen in the germline decreases early mortality and promotes the synthesis of a subset of proteins with known anti-aging roles, some of which have preferential expression in the germline. These findings indicate a contribution of specialized ribosomal proteins to the regulation of the muscle proteome during aging.
Keywords: aging / ribosome / protein translation / Drosophila / germline / skeletal muscle

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

Share this article

Click here to see the statistics on "G3 Genes|Genomes|Genetics" .
Back to Top Top