Immunoregulation by Artemisinin and Its Derivatives: A New Role for Old Antimalarial Drugs
Open Access
- 9 September 2021
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Immunology
Abstract
Artemisinin and its derivatives (ARTs) are known as conventional antimalarial drugs with clinical safety and efficacy. Youyou Tu was awarded a Nobel Prize in Physiology and Medicine due to her discovery of artemisinin and its therapeutic effects on malaria. Apart from antimalarial effects, mounting evidence has demonstrated that ARTs exert therapeutic effects on inflammation and autoimmune disorders because of their anti-inflammatory and immunoregulatory properties. In this aspect, tremendous progress has been made during the past five to seven years. Therefore, the present review summarizes recent studies that have explored the anti-inflammatory and immunomodulatory effects of ARTs on autoimmune diseases and transplant rejection. In this review, we also discuss the cellular and molecular mechanisms underlying the immunomodulatory effects of ARTs. Recent preclinical studies will help lay the groundwork for clinical trials using ARTs to treat various immune-based disorders, especially autoimmune diseases.This publication has 78 references indexed in Scilit:
- Investigation of ototoxicity of artesunate as add-on therapy in patients with metastatic or locally advanced breast cancer: new audiological results from a prospective, open, uncontrolled, monocentric phase I studyCancer Chemotherapy and Pharmacology, 2016
- Synthesis and in vitro antitumor evaluation of dihydroartemisinin-cinnamic acid ester derivativesEuropean Journal of Medicinal Chemistry, 2016
- Therapeutic effects of the artemisinin analog SM934 on lupus-prone MRL/lpr mice via inhibition of TLR-triggered B-cell activation and plasma cell formationCellular & Molecular Immunology, 2015
- Dihydroartemisinin inhibits activation of the Toll-like receptor 4 signaling pathway and production of type I interferon in spleen cells from lupus-prone MRL/lpr miceInternational Immunopharmacology, 2014
- Epidermal Th22 and Tc17 Cells Form a Localized Disease Memory in Clinically Healed PsoriasisThe Journal of Immunology, 2014
- Dihydroartemisinin-piperaquine for treating uncomplicated Plasmodium falciparum malariaEmergencias, 2014
- The discovery of artemisinin (qinghaosu) and gifts from Chinese medicineNature Medicine, 2011
- Epidemiology of Immune-Mediated Inflammatory Diseases: Incidence, Prevalence, Natural History, and ComorbiditiesThe Journal of Rheumatology, 2010
- Clearance of psoriasis with low dose cyclosporin.BMJ, 1986