Prevalence of Allelic and Genotypic Variants of Il4, Il10, Il12b and Tlr2 Gene Polymorphism in Patients with Chronic Polypoid Rhinosinusitis
Open Access
- 10 August 2021
- journal article
- Published by Lattice Science Publication (LSP) in International Journal of Advanced Dental Sciences and Technology
- Vol. 1 (2), 11-19
- https://doi.org/10.54105/ijadst.b1004.081221
Abstract
Chronic polyposis rhinosinusitis (CPRS) is an important medical and social problem due to its prevalence, combination with other diseases (bronchial asthma, cystic fibrosis), prolonged recurrent course, which leads to a decrease in the quality of life and performance of patients. Bronchopulmonary, rhinogenic orbital and intracranial complications arising against the background of chronic sinusitis not only worsen the quality of life of patients, but also sometimes lead to long-term disability, and sometimes to disability. The results of our study demonstrated that the distribution of the genotypes of polymorphisms of all genes corresponded to the expected, i.e., in this case, the Hardy-Weinberg equilibrium is fulfilled in both groups. Both samples rs2243250 of the IL4 gene were characterized by high frequencies of the unfavorable C allele and the heterozygous T / C genotype, rs3212227 of the IL12B gene of the A allele and the heterozygous A / C genotype, rs1800895 592 C> A in the IL10 gene of the A, C alleles, and heterozygous C rs5743708 in the TLR2 gene of the C allele and the heterozygous C / T genotype, hence the high level of genetic variability of the studied genes.Keywords
This publication has 18 references indexed in Scilit:
- Functional characterization of genetic enzyme variations in human lipoxygenasesRedox Biology, 2013
- Genetics of chronic rhinosinusitis: State of the field and directions forwardJournal of Allergy and Clinical Immunology, 2013
- Non-HLA gene polymorphisms and their implications on dengue virus infectionEgyptian Journal of Medical Human Genetics, 2013
- The genetics of asthma and allergic disease: a 21st century perspectiveImmunological Reviews, 2011
- Demonstration Of A Common Genetic Basis To CRS In Chinese And Caucasian PopulationsJournal of Allergy and Clinical Immunology, 2011
- Association of IL1A, IL1B, and TNF Gene Polymorphisms With Chronic Rhinosinusitis With and Without Nasal PolyposisJAMA Otolaryngology–Head & Neck Surgery, 2010
- Evidence of Association of Interleukin-1 Receptor-Like 1 Gene Polymorphisms with Chronic RhinosinusitisAmerican Journal of Rhinology and Allergy, 2009
- Identification of susceptibility genes for complex diseases using pooling-based genome-wide association scansHuman Genetics, 2009
- Association between a TGFβ1 promoter polymorphism and rhinosinusitis in aspirin-intolerant asthmatic patientsRespiratory Medicine, 2007
- The diagnosis and management of sinusitis: A practice parameter updateJournal of Allergy and Clinical Immunology, 2005