Use of the leaves of Alchornea cordifolia (Schumach. & Thonn.) Müll (Euphorbiaceae) and prospects for treatment of infections due to multidrug-resistant bacteria
Open Access
- 12 May 2022
- journal article
- research article
- Published by Springer Science and Business Media LLC in Bulletin of the National Research Centre
- Vol. 46 (1), 1-7
- https://doi.org/10.1186/s42269-022-00821-0
Abstract
Background: Africa has a rich and diverse flora that people use for their food and health needs. This study aims to explore the possibility of using aqueous and/or ethanolic extracts of Alchornea cordifolia leaves as an alternative in the fight against multi-resistant bacteria responsible for gastritis and urinary tract infections. Results: The results show that 100% of the tested bacilli (E. coli, K. pneumoniae, P. aeruginosa) are resistant to the 10 antibiotic disks tested. This resistance is 66.66% for quinolones and fluoroquinolones. S. aureus was found to be resistant to glycopeptides and aminoglycosides. Three ESBL genes are identified in bacilli against only one type of ESBL gene in cocci. 100% of the bacilli carry the SHV genes, and S. aureus has the Mec A gene. The aqueous extract exerted a bactericidal effect on all the strains with MICs and BMCs varying, respectively, from 0.76 to 50 mg/ml and BMCs from 0.76 to 100 mg/ml. Only 40% of the chemical groups (tannin, flavonoids, mucilages and sterol-terpenes) sought were present in the aqueous extract. The ethanolic extract is not active. Conclusions: Based on these data, the aqueous extract of A. cordifolia leaves is a good phytomedical candidate for the treatment of gastritis (stomach cramps, watery or bloody diarrhea) and urinary tract infections caused by multi-resistant Gram-negative and Gram-positive bacteria.Keywords
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