In vivo evaluation of bone microstructure in humans: Clinically useful?
- 15 June 2016
- journal article
- review article
- Published by Portico in BoneKEy Reports
- Vol. 5, 813
- https://doi.org/10.1038/bonekey.2016.40
Abstract
In vivo evaluation of bone microstructure with high-resolution peripheral quantitative tomography (HRpQCT) has been used for a decade in research settings. In this review, we examine the value this technique could have in clinical practice. Bone microstructure parameters obtained with HRpQCT are associated with prevalent fracture in men and women. In postmenopausal women, some parameters also predict incident fracture, independently of areal bone mineral density. In specific population groups including patients with diabetes, chronic kidney disease, glucocorticosteroid therapy and rheumatic diseases, abnormal microstructure parameters from HRpQCT have been reported. Findings from HRpQCT studies may also explain ethnic differences in bone fragility. Treatment monitoring has been challenging in the various clinical trials with available HRpQCT data. The improvements were of small magnitude but tended to be proportional to the potency of antiresorptive agents. Microfinite element analysis was a better predictor of treatment efficacy than the microarchitectural parameters. In conclusion, HRpQCT remains a valuable research tool, but more work is needed to be able to use it in clinical practice.Keywords
This publication has 41 references indexed in Scilit:
- Bone microarchitecture in ankylosing spondylitis and the association with bone mineral density, fractures, and syndesmophytesArthritis Research & Therapy, 2013
- Increased cortical porosity in type 2 diabetic postmenopausal women with fragility fracturesJournal of Bone and Mineral Research, 2012
- Relationship between bone mineral density changes with denosumab treatment and risk reduction for vertebral and nonvertebral fracturesJournal of Bone and Mineral Research, 2011
- Bone structure and turnover in type 2 diabetes mellitusOsteoporosis International, 2011
- Better skeletal microstructure confers greater mechanical advantages in Chinese-American women versus white womenJournal of Bone and Mineral Research, 2011
- A longitudinal HR-pQCT study of alendronate treatment in postmenopausal women with low bone density: Relations among density, cortical and trabecular microarchitecture, biomechanics, and bone turnoverJournal of Bone and Mineral Research, 2010
- High-Resolution Peripheral Quantitative Computed Tomographic Imaging of Cortical and Trabecular Bone Microarchitecture in Patients with Type 2 Diabetes MellitusJournal of Clinical Endocrinology & Metabolism, 2010
- Bone Mass and Microarchitecture in CKD Patients with FractureJournal of the American Society of Nephrology, 2010
- Early impairment of trabecular microarchitecture assessed with HR-pQCT in patients with stage II-IV chronic kidney diseaseJournal of Bone and Mineral Research, 2010
- High-Resolution pQCT Analysis at the Distal Radius and Tibia Discriminates Patients With Recent Wrist and Femoral Neck FracturesJournal of Bone and Mineral Research, 2008